CellDent

March 27, 2020 Oakland, CA – In response to the crisis caused by the COVID-19 virus in California and around the world the governing Board of the California Institute for Regenerative Medicine (CIRM) today held an emergency meeting to approve $5 million in rapid research funds targeting the virus. “These are clearly extraordinary times and […]

December 16, 2019 Oakland, CA – Ysabel Duron, a pioneering award-winning Latina journalist, and a leading figure in cancer education in the Latino community in the US, has been appointed to the governing Board of the California Institute for Regenerative Medicine.   State Controller Betty Yee made the appointment saying: “Ms. Duron’s personal perspective as […]

December 13, 2019 Oakland, CA – There are a growing number of predatory clinics in California and around the US, offering unproven stem cell therapies. For patients seeking a legitimate therapy it can often be hard finding a reliable clinic, one offering treatments based on the rigorous science required in a clinical trial sanctioned by […]

Oakland, CA – The governing Board of the California Institute for Regenerative Medicine (CIRM) today invested $32.92 million to fund the Stem Cell Agency’s first clinical trial in Parkinson’s disease (PD), and to support three clinical trials targeting different forms of vision loss. This brings the total number of clinical trials funded by CIRM to […]

October 9, 2019 Oakland, CA – An independent Economic Impact Report says the California Institute for Regenerative Medicine (CIRM) has had a major impact on California’s economy, creating tens of thousands of new jobs, generating hundreds of millions of dollars in new taxes, and producing billions of dollars in additional revenue for the state. The […]

Oakland, CA – Today the governing Board of the California Institute for Regenerative Medicine (CIRM) awarded $9.28 million to Dr. Saul Priceman at City of Hope to conduct a clinical trial for the treatment of breast cancer related brain metastases, which are tumors in the brain that have spread from the original site of the […]

Oakland, CA – Today the governing Board of the California Institute for Regenerative Medicine (CIRM) approved a grant of almost $12 million to Dr. Stephanie Cherqui at the University of California, San Diego (UCSD) to conduct a clinical trial for treatment of cystinosis. This award brings the total number of CIRM funded clinical trials to […]

Oakland, CA - Today the governing Board of the California Institute for Regenerative Medicine (CIRM) awarded $11.08 Million to Dr. Peter Stock at the University of California San Francisco (UCSF) to conduct a clinical trial for treatment of Type 1 Diabetes (T1D). The award brings the total number of CIRM funded clinical trials to 54.  T1D […]

Oakland, CA – On April 29th, the governing Board of the California Institute for Regenerative Medicine (CIRM) awarded two grants totaling $11.15 million to carry out two new clinical trials.  These latest additions bring the total number of CIRM funded clinical trials to 53.  $6.56 Million was awarded to Rocket Pharmaceuticals, Inc. to conduct a […]

CIRM Board approves first program eligible for co-funding under  the agreement Oakland, CA – Sickle Cell disease (SCD) is a  painful, life-threatening blood disorder that affects around 100,000 people, mostly African Americans, in the US. Even with optimal medical care, SCD shortens expected lifespan by decades.  It is caused by a single genetic mutation that […]

Scientists have identified a new control mechanism that enables stem cells to adapt their activity in emergency situations. For this purpose, the stem cells simultaneously modify the blueprints for hundreds of proteins encoded in the gene transcripts. In this way, they control the amount of protein produced and can also control the formation of certain […]

Medical researchers have developed an 'in vivo priming' with heart-derived bioink. Using engineered stem cells and 3D bioprinting technology, they began developing medicines for cardiovascular diseases.

Researchers have discovered a way to refine the production of retinal cells from embryonic stem cells for treating blindness in the elderly. Using the CRISPR/Cas9 gene editing, they have also managed to modify the cells so that they can hide from the immune system to prevent rejection.

A stem cell biologist from City University of Hong Kong (CityU), together with his collaborators, has developed a novel strategy, called in vivo priming, to 'train' the stem cells to stay strong after implantation to the damaged heart via the 3D-printed bandage-like patch. The positive results of the study show that an in vivo priming […]

Researchers have developed a stem cell therapy on myocardial infarction, using proteins that can be found in mussels, mussel adhesive proteins.

Researchers have developed and validated a novel PITX2-eGFP hiPSC reporter line to model the development of periocular mesenchymal cells. These findings could help understand how the eye develops during embryogenesis and how it changes during disease processes.

Researchers show that different stem cell populations are innervated in distinct ways. Innervation may therefore be crucial for proper tissue regeneration. They also demonstrate that cancer stem cells likewise establish contacts with nerves. Targeting tumor innervation could thus lead to new cancer therapies.

A new study suggests that the age of certain immune cells used in immunotherapy plays a role in how effective it is. These cells -- natural killer (NK) cells -- appear to be more effective the earlier they are in development, opening the door to the possibility of an immunotherapy that would not utilize cells […]

Researchers have published the first comprehensive overview of the major changes that occur in mammalian skin cells as they prepare to heal wounds. Results from the study provide a blueprint for future investigation into pathological conditions associated with poor wound healing, such as in diabetic patients.

With the help of photolithography and programmable DNA, researchers have created a new technique that can rapidly 'print' two-dimensional arrays of cells and proteins that mimic a wide variety of cellular environments in the body. This technique could help scientists develop a better understanding of the complex cell-to-cell messaging that dictates a cell's final fate.

Scientists have revealed that a bacterial superbug can prevent stem cells in the gut from carrying out their vital role of regenerating the inner lining of the intestine.

Scientists have uncovered a surprising property of blood stem cells: not only do they ensure the continuous renewal of blood cells and contribute to the immune response triggered by an infection, but they can also remember previous infectious encounters to drive a more rapid and more efficient immune response in the future.

Researchers have uncovered stem cell-activated mechanisms of healing after a heart attack. Stem cells restored cardiac muscle back to its condition before the heart attack, in turn providing a blueprint of how stem cells may work.

A team of researchers recently proved the ability to grow human-derived blood vessels in a pig -- a novel approach that has the potential for providing unlimited human vessels for transplant purposes.

A study of the second HIV patient to undergo successful stem cell transplantation from donors with a HIV-resistant gene, finds that there was no active viral infection in the patient's blood 30 months after they stopped anti-retroviral therapy, according to a case report.

Scientists have sent adult human stem cells to the International Space Station (ISS). Researchers will explore the production of human tissue in weightlessness.

Scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes. The findings from this experimental study, they say, advance regenerative medicine techniques […]

A population of stem cells with the ability to generate new bone has been newly discovered by a group of researchers.

Researchers have analyzed all cell types in the human ovary and found that the hotly debated so-called egg stem cells do not exist.

A new study shows that lung stem cell secretions -- specifically exosomes and secretomes -- delivered via nebulizer, can help repair lung injuries due to multiple types of pulmonary fibrosis in mice and rats.

by Angélique Volfart, Jacques Jonas, Louis Maillard, Sophie Colnat-Coulbois, Bruno Rossion Putting a name to a face is a highly common activity in our daily life that greatly enriches social interactions. Although this specific person–identity association becomes automatic with learning, it remains difficult and can easily be disrupted in normal circumstances or neurological conditions. To […]

by Konrad Wagstyl, Stéphanie Larocque, Guillem Cucurull, Claude Lepage, Joseph Paul Cohen, Sebastian Bludau, Nicola Palomero-Gallagher, Lindsay B. Lewis, Thomas Funck, Hannah Spitzer, Timo Dickscheid, Paul C. Fletcher, Adriana Romero, Karl Zilles, Katrin Amunts, Yoshua Bengio, Alan C. Evans Histological atlases of the cerebral cortex, such as those made famous by Brodmann and von Economo, […]

by Ester M. Eckert, Andrea Di Cesare, Diego Fontaneto, Thomas U. Berendonk, Helmut Bürgmann, Eddie Cytryn, Despo Fatta-Kassinos, Andrea Franzetti, D. G. Joakim Larsson, Célia M. Manaia, Amy Pruden, Andrew C. Singer, Nikolina Udikovic-Kolic, Gianluca Corno Have you ever sought to use metagenomic DNA sequences reported in scientific publications? Were you successful? Here, we reveal […]

by Simon P. Ripperger, Gerald G. Carter, Rachel A. Page, Niklas Duda, Alexander Koelpin, Robert Weigel, Markus Hartmann, Thorsten Nowak, Jörn Thielecke, Michael Schadhauser, Jörg Robert, Sebastian Herbst, Klaus Meyer-Wegener, Peter Wägemann, Wolfgang Schröder-Preikschat, Björn Cassens, Rüdiger Kapitza, Falko Dressler, Frieder Mayer Recent advances in animal tracking technology have ushered in a new era in […]

by Carlos Sonnenschein, Ana M. Soto Despite over a century of intensive efforts, the great gains promised by the War on Cancer nearly 50 years ago have not materialized. Since 1999, we have analyzed the lack of progress in explaining and “curing” cancer by examining the merits of the premises that determine how cancer is […]

by Joseph S. Snowden, Daniel L. Hurdiss, Oluwapelumi O. Adeyemi, Neil A. Ranson, Morgan R. Herod, Nicola J. Stonehouse Icosahedral viral capsids must undergo conformational rearrangements to coordinate essential processes during the viral life cycle. Capturing such conformational flexibility has been technically challenging yet could be key for developing rational therapeutic agents to combat infections. […]

by Nonia Pariente, on behalf of the PLOS Biology Staff Editors

by Pallavi Kompella, Brant Gracia, Lucy LeBlanc, Shelly Engelman, Chinmayee Kulkarni, Niral Desai, Viviana June, Stephen March, Sarah Pattengale, Gabriel Rodriguez-Rivera, Seung Woo Ryu, Isabel Strohkendl, Pooja Mandke, Greg Clark Science communication and outreach are essential for training the next generation of scientists and raising public awareness for science. Providing effective science, technology, engineering, and […]

by Pedro Tiago Martins, Cedric Boeckx Vocal learning is the ability to modify vocal output on the basis of experience. Traditionally, species have been classified as either displaying or lacking this ability. A recent proposal, the vocal learning continuum, recognizes the need to have a more nuanced view of this phenotype and abandon the yes–no […]

by Ziying Hu, Shuai Wang, Chengdong Zhang, Ning Gao, Miaomiao Li, Deqian Wang, Daqi Wang, Dong Liu, Huihui Liu, Sang-Ging Ong, Hongyan Wang, Yongming Wang Compact CRISPR/Cas9 systems that can be packaged into an adeno-associated virus (AAV) hold great promise for gene therapy. Unfortunately, currently available small Cas9 nucleases either display low activity or require […]

by Peter J. Hotez In the last half of the 2010s, we saw an upswing in antiscience movements and unprecedented attacks on scientists in the United States and elsewhere. All indications suggest that this trend will not slow or reverse anytime soon, and it is now increasingly apparent that it will fall to the scientists […]

by Bo Xia, Xiao Chen Shi, Bao Cai Xie, Meng Qing Zhu, Yan Chen, Xin Yi Chu, Guo He Cai, Min Liu, Shi Zhen Yang, Grant A. Mitchell, Wei Jun Pang, Jiang Wei Wu Obesity leads to multiple health problems, including diabetes, fatty liver, and even cancer. Here, we report that urolithin A (UA), a […]

by Brian A. Nosek, Timothy M. Errington Credibility of scientific claims is established with evidence for their replicability using new data. According to common understanding, replication is repeating a study’s procedure and observing whether the prior finding recurs. This definition is intuitive, easy to apply, and incorrect. We propose that replication is a study for […]

by Ulrich Dirnagl Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the results, they can help with antagonizing inadequate statistical power, selective reporting of results, undisclosed analytic flexibility, as well as […]

by Christopher D. Chambers Prestigious scientific journals traditionally decide which articles to accept at least partially based on the results of research. This backloaded selectivity enforces publication bias and encourages authors to selectively report their most persuasive findings, even when they are misleading, biased, and unreliable. One answer to backloaded selectivity is to curtail editorial […]

by Li Zhang, Qiwen Wu, Yifeng Zhang Gap junction connections between neurons play critical roles in the development of the nervous system. However, studies on the sensory experience–driven plasticity during the critical period rarely examine the involvement of gap junction connections. ON-OFF direction selective ganglion cells (ooDSGCs) in the mouse retina that prefer upward motion […]

by Karin Schneeberger, Gregory Röder, Michael Taborsky When individuals exchange helpful acts reciprocally, increasing the benefit of the receiver can enhance its propensity to return a favour, as pay-offs are typically correlated in iterated interactions. Therefore, reciprocally cooperating animals should consider the relative benefit for the receiver when deciding to help a conspecific. Norway rats […]

by Arles Urrutia, Víctor A. García-Angulo, Andrés Fuentes, Mauricio Caneo, Marcela Legüe, Sebastián Urquiza, Scarlett E. Delgado, Juan Ugalde, Paula Burdisso, Andrea Calixto Caenorhabditis elegans and its cognate bacterial diet comprise a reliable, widespread model to study diet and microbiota effects on host physiology. Nonetheless, how diet influences the rate at which neurons die remains […]

by Candelas Álvarez-Salamero, Raquel Castillo-González, Gloria Pastor-Fernández, Isabel R. Mariblanca, Jesús Pino, Danay Cibrian, María N. Navarro Interleukin 23 (IL-23) triggers pathogenic features in pro-inflammatory, IL-17-secreting T cells (Th17 and Tγδ17) that play a key role in the development of inflammatory diseases. However, the IL-23 signaling cascade remains largely undefined. Here, we used quantitative phosphoproteomics […]

by Paulo A. Navarro-Costa, Antoine Molaro, Chandra S. Misra, Colin D. Meiklejohn, Peter J. Ellis During in vitro fertilisation (IVF), pharmacological activation of the murine X chromosome–encoded receptor proteins Toll-like receptor (TLR) 7 and TLR8 reportedly results in male-biased litters by selectively disrupting the motility of X-bearing sperm cells. Thus—in the context of agonist treatment […]